Medicine and Health

Immunomodulatory activity of a water-soluble polysaccharide extracted from mussel on cyclophosphamide-induced immunosuppressive mice models

X. Xiang, R. Wang, et al.

Discover how mussel polysaccharide can protect against cyclophosphamide-induced immunosuppression and microbial imbalances. This innovative study by Xingwei Xiang, Rui Wang, Lin Chen, Yufeng Chen, Bin Zheng, Shanggui Deng, Shulai Liu, Peilong Sun, and Guoxin Shen reveals the potential of MP to enhance immunity and improve gut health.

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Abstract

This study investigated the protective effect of mussel polysaccharide (MP) on cyclophosphamide (Cy)-induced intestinal mucosal immunosuppression and microbial dysbiosis in mice. MP stimulated cytokine secretion (SIgA, IL-2, IF-γ, IL-4, IL-10) and transcription factor production (occludin, claudin-1, ZO-1, mucin-2, IL-2, IF-γ, IL-4, IL-10), upregulating key NF-κB pathway proteins (p-IκB-α, p-p65). MP improved SCFA levels and, according to 16S rRNA sequencing, enhanced microbial diversity, increasing probiotics (*Lactobacillus*) and decreasing pathogens (*Desulfovibrio*). MP shows potential immunomodulatory activity.

Publisher

npj Science of Food

Published On

Apr 27, 2022

Authors

Xingwei Xiang, Rui Wang, Lin Chen, Yufeng Chen, Bin Zheng, Shanggui Deng, Shulai Liu, Peilong Sun, Guoxin Shen

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