Medicine and Health

Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin

N. Harada, M. Okuyama, et al.

This groundbreaking study by Naoki Harada and colleagues reveals that GPR55 is a crucial target for curcumin. It demonstrates how curcumin activates GPR55 to induce transcription while uncovering the vital roles of specific molecular structures. This research offers exciting insights into the physiological functions of curcumin.

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Playback language: English

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Abstract

This study identified GPR55 as a target for curcumin using a developed screening system. Curcumin activated GPR55, inducing transcription, inhibited by Rho kinase and GPR55 antagonists. Both the methoxy group and heptadienone moiety were crucial for activation, with F190<sup>5.47</sup> of GPR55 important for interaction. Curcumin-induced GLP-1 secretion was inhibited by a GPR55 antagonist, suggesting GPR55's involvement in curcumin's physiological function.

Publisher

npj Science of Food

Published On

Jan 14, 2022

Authors

Naoki Harada, Mai Okuyama, Yoshiaki Teraoka, Yumi Arahori, Yoh Shinmori, Hiroko Horiuchi, Paula B. Luis, Akil I. Joseph, Tomoya Kitakaze, Shigenobu Matsumura, Tohru Hira, Norio Yamamoto, Takashi Iuni, Naoki Goshima, Claus Schneider, Hiroshi Inui, Ryoichi Yamaji

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