Medicine and Health

Human heart-forming organoids recapitulate early heart and foregut development

L. Drakhlis, S. Biswanath, et al.

This innovative study highlights the creation of intricate, three-dimensional heart-forming organoids derived from human pluripotent stem cells, mimicking crucial heart and foregut development stages. Conducted by a team of experts, including Lika Drakhlis and Santoshi Biswanath, this research opens new pathways for understanding human heart development and related diseases.

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Abstract

This study reports the generation of complex, three-dimensional heart-forming organoids (HFOs) from human pluripotent stem cells. These HFOs recapitulate early heart and foregut development, including myocardial, endocardial-like, septum transversum-like layers, and distinct anterior and posterior foregut endoderm tissues. The researchers used NKX2.5 knockout HFOs to study genetic defects, observing a phenotype similar to cardiac malformations seen in transgenic mice. The HFO model offers a novel platform for studying human cardiogenesis and disease.

Publisher

Nature Biotechnology

Published On

Jun 01, 2021

Authors

Lika Drakhlis, Santoshi Biswanath, Clara-Milena Farr, Victoria Lupanow, Jana Teske, Katharina Ritzenhoff, Annika Franke, Felix Manstein, Emiliano Bolesani, Henning Kempf, Simone Liebscher, Katja Schenke-Layland, Jan Hegermann, Lena Nolte, Heiko Meyer, Jeanne de la Roche, Stefan Thiemann, Christian Wahl-Schott, Ulrich Martin, Robert Zweigerdt

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