Hollow silica reinforced magnesium nanocomposites with enhanced mechanical and biological properties with computational modeling analysis for mandibular reconstruction

The present study investigates Mg-SiO₂ nanocomposites as biodegradable implants for orthopedic and maxillofacial applications. The effect of presence and progressive addition of hollow silica nanoparticles (0.5, 1, and 1.5) vol.% on the microstructural, mechanical, degradation, and biocompatibility response of pure Mg were investigated. Results suggest that the increased addition of hollow silica nanoparticles resulted in a progressive increase in yield strength and ultimate compressive strength with Mg-1.5 vol.% SiO₂ exhibiting superior enhancement. The response of Mg-SiO₂ nanocomposites under the influence of Hanks' balanced salt solution revealed that the synthesized composites revealed lower corrosion rates, indicating rapid dynamic passivation when compared with pure Mg. Furthermore, cell adhesion and proliferation of osteoblast cells were noticeably higher than pure Mg with the addition of 1 vol.% SiO₂ nanoparticle. The biocompatibility and the in vitro biodegradation of the Mg-SiO₂ nanocomposites were influenced by the SiO₂ content in pure Mg with Mg-0.5 vol.% SiO₂ nanocomposite exhibiting the best corrosion resistance and biocompatibility when compared with other nanocomposites. Enhancement in mechanical, corrosion, and biocompatibility characteristics of Mg-SiO₂ nanocomposites developed in this study are also compared with properties of other metallic biomaterials used in alloplastic mandibular reconstruction in a computational model.

Somasundaram Prasadh, Vyasaraj Manakari, Gururaj Parande, Raymond Chung Wen Wong, Manoj Gupta