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Highly demarcated structural alterations in the brain and impaired social incentive learning in *Tbx1* heterozygous mice

Psychology

Highly demarcated structural alterations in the brain and impaired social incentive learning in *Tbx1* heterozygous mice

T. Hiramoto, A. Sumiyoshi, et al.

Discover how *Tbx1*, a gene within the 22q11.2 CNV region, influences brain structure and behavior in a groundbreaking study conducted by Takeshi Hiramoto and colleagues. Their findings reveal significant alterations in brain volumes and behavioral impairments linked to social learning and sensory processing, deepening our understanding of psychiatric disorders.

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Playback language: English
Abstract
Copy number variants (CNVs) are strongly linked to psychiatric disorders and brain structural changes. This study investigated the contribution of *Tbx1*, a gene within the 22q11.2 CNV region, to these alterations using *Tbx1* heterozygous mice. Volumetric MRI revealed reduced amygdala volumes (anterior and posterior) and increased auditory cortex volumes. Behaviorally, these mice showed impaired social incentive learning and acoustic sensorimotor gating, but not non-acoustic gating. These findings highlight *Tbx1*'s role in brain structure and specific behavioral dimensions.
Publisher
Molecular Psychiatry
Published On
Oct 27, 2024
Authors
Takeshi Hiramoto, Akira Sumiyoshi, Risa Kato, Takahira Yamauchi, Takeshi Takano, Gina Kang, Marisa Esparza, Bailey Matsumura, Lucas J. Stevens, Yukiko J. Hiroi, Takaki Tanifuji, Rie Ryoke, Hiroi Nonaka, Akihiro Machida, Kensaku Nomoto, Kazutaka Mogi, Takefumi Kikusui, Ryuta Kawashima, Noboru Hiroi
Tags
Tbx1
copy number variants
psychiatric disorders
brain structure
behavioral dimensions
social incentive learning
auditory cortex

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