Medicine and Health

Health-related quality of life, psychological distress, and fatigue in metastatic castration-resistant prostate cancer patients treated with radium-223 therapy

M. J. V. D. Doelen, I. M. Oving, et al.

This multicenter, prospective observational study reveals critical insights into health-related quality of life (HR-QoL), psychological distress, and fatigue among metastatic castration-resistant prostate cancer patients treated with radium-223. The findings indicate that those who discontinued treatment faced significant declines in HR-QoL and well-being over time. Conducted by an expert team of researchers including Maarten J. van der Doelen and Judith B. Prins, this study uncovers important predictive factors for HR-QoL deterioration.

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Abstract

This multicenter, prospective observational cohort study evaluated health-related quality of life (HR-QoL), psychological distress, and fatigue in metastatic castration-resistant prostate cancer (mCRPC) patients treated with radium-223. Patients who discontinued radium-223 therapy showed worse HR-QoL, psychological distress, and fatigue at baseline and experienced frequent deterioration over time compared to those who completed therapy. Opioid use, low hemoglobin, and high alkaline phosphatase levels before treatment predicted HR-QoL deterioration.

Publisher

Prostate Cancer and Prostatic Diseases

Published On

Jul 08, 2022

Authors

Maarten J. van der Doelen, Irma M. Oving, Dirk N. J. Wyndaele, Jean-Paul van Basten, Frederik Terheggen, Addy C. M. van de Luijtgaarden, Wim J. G. Oyen, W. Dick van Schelven, Franchette van den Berkmortel, Niven Mehra, Marcel J. R. Janssen, Judith B. Prins, Winald R. Gerritsen, José A. E. Custers, Inge M. van Oort

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