Medicine and Health

Gut Failure: A Review of the Pathophysiology and Therapeutic Potentials in the Gut-Heart Axis

A. Day, B. Lauer, et al.

Discover how low-grade inflammation from the gut may influence heart failure progression in a groundbreaking review by Andrew Day and colleagues. This research delves into the gut-heart axis, revealing intriguing links between microbiota dysbiosis and cardiac dysfunction, while proposing innovative therapeutic strategies to enhance heart failure management.

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Playback language: English

Index

Abstract

Heart failure (HF) remains a leading cause of cardiovascular morbidity and mortality. Low-grade inflammation, potentially originating from the gut, is implicated in HF progression. This review explores the gut-heart axis, focusing on microbiota dysbiosis, intestinal barrier dysfunction, and systemic inflammation in HF. It summarizes the pathophysiological mechanisms linking gut derangements to cardiac dysfunction and proposes therapeutic interventions targeting the gut-heart axis to improve HF management.

Publisher

Journal of Clinical Medicine

Published On

Mar 29, 2023

Authors

Andrew Day, Bernward Lauer, Dionysis Matsiras, Sofia Bezati, Ioannis Ventoulis, Christos Verras, John Parissis, Effie Polyzogopoulou

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