Heart failure (HF) remains a leading cause of cardiovascular morbidity and mortality. Low-grade inflammation, potentially originating from the gut, is implicated in HF progression. This review explores the gut-heart axis, focusing on microbiota dysbiosis, intestinal barrier dysfunction, and systemic inflammation in HF. It summarizes the pathophysiological mechanisms linking gut derangements to cardiac dysfunction and proposes therapeutic interventions targeting the gut-heart axis to improve HF management.
Publisher
Journal of Clinical Medicine
Published On
Mar 29, 2023
Authors
Andrew Day, Bernward Lauer, Dionysis Matsiras, Sofia Bezati, Ioannis Ventoulis, Christos Verras, John Parissis, Effie Polyzogopoulou
Tags
heart failure
inflammation
gut microbiota
intestinal barrier
systemic inflammation
cardiac dysfunction
therapeutic interventions
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