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Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation

Medicine and Health

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation

A. Trompette, J. Pernot, et al.

Discover how a fiber-rich diet can alleviate atopic dermatitis (AD) by strengthening skin barrier functions, thanks to gut-derived short-chain fatty acids like butyrate. This groundbreaking research conducted by Aurélien Trompette, Julie Pernot, and others reveals exciting new insights into skin health.

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Playback language: English
Abstract
Impaired skin barrier function is linked to allergic diseases like atopic dermatitis (AD). This study demonstrates that a fermentable fiber-rich diet alleviates AD-like skin inflammation and systemic allergen sensitization in mice. This is mediated by gut-derived short-chain fatty acids (SCFAs), particularly butyrate, which strengthens the skin barrier by modulating keratinocyte metabolism and differentiation, enhancing production of structural proteins and lipids.
Publisher
Mucosal Immunology
Published On
Jun 07, 2022
Authors
Aurélien Trompette, Julie Pernot, Olaf Perdijk, Rayed Ali A. Alqahtani, Jaime Santo Domingo, Dolores Camacho-Muñoz, Nicholas C. Wong, Alexandra C. Kendall, Andreas Wiederkehr, Laurent P. Nicod, Anna Nicolaou, Christophe von Garnier, Niki D. J. Ubags, Benjamin J. Marsland
Tags
atopic dermatitis
gut health
short-chain fatty acids
skin barrier
fermentable fiber
immune response

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