Gut-derived short-chain fatty acids modulate skin barrier | ResearchBunny

Index

Abstract

Impaired skin barrier function is linked to allergic diseases like atopic dermatitis (AD). This study demonstrates that a fermentable fiber-rich diet alleviates AD-like skin inflammation and systemic allergen sensitization in mice. This is mediated by gut-derived short-chain fatty acids (SCFAs), particularly butyrate, which strengthens the skin barrier by modulating keratinocyte metabolism and differentiation, enhancing production of structural proteins and lipids.

Publisher

Mucosal Immunology

Published On

Jun 07, 2022

Authors

Aurélien Trompette, Julie Pernot, Olaf Perdijk, Rayed Ali A. Alqahtani, Jaime Santo Domingo, Dolores Camacho-Muñoz, Nicholas C. Wong, Alexandra C. Kendall, Andreas Wiederkehr, Laurent P. Nicod, Anna Nicolaou, Christophe von Garnier, Niki D. J. Ubags, Benjamin J. Marsland

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