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Abstract
To trace the evolution of coronaviruses and reveal the possible origin of SARS-CoV-2, we analyzed 29,452 coronavirus genomes. We observed three significant recombination events between human, bat, and pangolin isolates, including a recombination in the spike glycoprotein's receptor-binding domain (RBD), potentially explaining SARS-CoV-2's origin. Population genetic analyses suggest directional evolution of this RBD sequence, indicating viral adaptation to hosts. The high diversity of the RBD region in bat coronaviruses highlights their role as a reservoir of genetic diversity for SARS-CoV-2.
Publisher
Scientific Reports
Published On
Dec 10, 2020
Authors
Zhenglin Zhu, Kaiwen Meng, Geng Meng
Tags
coronaviruses
SARS-CoV-2
recombination
spike glycoprotein
viral evolution
genetic diversity

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