Engineering and Technology

Generation of tumor spheroids using a droplet-based microfluidic device for photothermal therapy

J. M. Lee, J. W. Choi, et al.

This innovative study introduces a droplet-based microfluidic device capable of generating uniform cell spheroids at an impressive frequency of 70 Hz. Conducted by authors from Sogang University, this research showcases the device's potential in photothermal therapy for brain tumors and versatile applications in drug screening.

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Abstract

This paper presents a droplet-based microfluidic device for automated, large-scale generation of homogenous cell spheroids. The device produces spheroids of 100-130 µm with a frequency of 70 Hz. The authors demonstrate its application in photothermal therapy (PTT) using brain tumor spheroids and a rGO-BPEI-PEG nanocomposite as the PTT agent. Uniformly sized neural stem cell-derived neurospheres were also generated, demonstrating the device's versatility for drug screening applications.

Publisher

Microsystems & Nanoengineering

Published On

Jan 28, 2020

Authors

Jong Min Lee, Ji Wook Choi, Christian D. Ahrberg, Hyung Woo Choi, Jang Ho Ha, Seok Gyu Mun, Sung Joon Mo, Bong Geun Chung

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