Medicine and Health

Formation of memory assemblies through the DNA-sensing TLR9 pathway

V. Jovasevic, E. M. Wood, et al.

This intriguing study reveals how the DNA-sensing TLR9 pathway plays a pivotal role in forming memory assemblies within hippocampal neurons. Researchers observed that learning triggers persistent double-stranded DNA breaks, leading to TLR9 activation, which is essential for memory function and neuronal health. Conducted by a diverse team of authors, this research uncovers how impaired TLR9 function may be linked to neurocognitive deficits.

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Playback language: English

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