Challenges in understanding three-dimensional (3D) brain networks by simultaneously recording both surface and intracortical areas of brain signals remain due to difficulties in constructing mechanical design and spatial limitations of implanted sites. This paper presents a foldable and flexible 3D neural prosthetic for 3D mapping of complex neural circuits with high spatiotemporal dynamics. The device integrates four flexible penetrating shanks and surface electrode arrays, demonstrating the potential to identify correlations of neural activities from the intracortical area to cortical regions. Synchronized signals of single spikes evoked by unidirectional total whisker stimulation were recorded, showcasing the platform's ability to clarify 3D neural pathways and offering a next-generation neural interface.

Ju Young Lee, Sang Hoon Park, Yujin Kim, Young Uk Cho, Jaejin Park, Jung-Hoon Hong, Kyubeen Kim, Jongwoon Shin, Jeong Eun Ju, In Sik Min, Mingyu Sang, Hyogeun Shin, Ui-Jin Jeong, Yuyan Gao, Bowen Li, Aizhan Zhumbayeva, Kyung Yeun Kim, Eun-Bin Hong, Min-Ho Nam, Hojeong Jeon, Youngmee Jung, Huanyu Cheng, Il-Joo Cho, Ki Jun Yu