Medicine and Health

Extension of efficacy range for targeted malaria-elimination interventions due to spillover effects

J. Benjamin-chung, H. Li, et al.

This research conducted by a team including Jade Benjamin-Chung and Haodong Li reveals groundbreaking insights into the effects of malaria interventions in Namibia. While direct impacts seem minimal, astonishing spillover effects were noted, with a 43% reduction in malaria incidence and a staggering 79% drop in prevalence near the intervention sites. This promising approach offers a broader benefit than ever anticipated!

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Abstract

This study re-analyzed a cluster-randomized trial of reactive, focal malaria interventions in Namibia to assess direct and spillover effects. While direct effects were weak or absent, strong evidence of spillover effects was found for combined chemoprevention (artemether-lumefantrine) and indoor residual spraying (pirimiphos-methyl). The combined intervention reduced malaria incidence by 43% within 1 km and prevalence by 79% within 3 km of index cases. Accounting for spillover effects increased the intervention's cost-effectiveness by 42%. Targeting hotspots with this combined approach benefits a wider area than initially anticipated.

Publisher

Nature Medicine

Published On

Oct 01, 2024

Authors

Jade Benjamin-Chung, Haodong Li, Anna Nguyen, Gabriella Barratt Heitmann, Adam Bennett, Henry Ntuku, Lisa M. Prach, Munyaradzi Tambo, Lindsey Wu, Chris Drakeley, Roly Gosling, Davis Mumbengegwi, Immo Kleinschmidt, Jennifer L. Smith, Alan Hubbard, Mark van der Laan, Michelle S. Hsiang

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