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Abstract
This study investigates the molecular mechanisms behind muscle atrophy in mice during spaceflight, focusing on the dysregulation of calcium levels and SERCA pump function. Using multi-omics data (transcriptomics, proteomics, and DNA methylation) from mouse soleus and tibialis anterior muscles exposed to microgravity, the researchers employed the QLattice symbolic regression algorithm to build explainable models predicting calcium reuptake. Acyp1 and Rps7 proteins emerged as key predictive biomarkers for tibialis anterior muscle resilience in space. These findings could inform interventions to mitigate muscle atrophy during space travel.
Publisher
npj Microgravity
Published On
Dec 13, 2023
Authors
Kevin Li, Riya Desai, Ryan T. Scott, Joel Ricky Steele, Meera Machado, Samuel Demharter, Adrienne Hoarfrost, Jessica L. Braun, Val A. Fajardo, Lauren M. Sanders, Sylvain V. Costes
Tags
muscle atrophy
spaceflight
calcium levels
SERCA pump
biomarkers
microgravity
multi-omics

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