logo
ResearchBunny Logo
Expedited synthesis of α-amino acids by single-step enantioselective α-amination of carboxylic acids

Chemistry

Expedited synthesis of α-amino acids by single-step enantioselective α-amination of carboxylic acids

C. Ye, D. R. Dansby, et al.

Discover a groundbreaking approach to synthesizing high-value α-amino acids in a single step! This research, conducted by Chen-Xi Ye, Drew R. Dansby, Shuming Chen, and Eric Meggers, harnesses iron catalysis and abundant carboxylic acids to provide an efficient and eco-friendly solution in the field of organic chemistry.

00:00
00:00
Playback language: English
Abstract
This paper reports a highly stereocontrolled, iron-catalyzed direct α-amination of carboxylic acid feedstock molecules, providing a single-step synthesis of high-value *N*-Boc-protected α-monosubstituted and α,α-disubstituted α-amino acids. The method uses abundant carboxylic acids, sustainable and earth-abundant iron catalysis, and the commonly used Boc protecting group, making it highly efficient and environmentally friendly.
Publisher
Nature Synthesis
Published On
Jul 01, 2023
Authors
Chen-Xi Ye, Drew R. Dansby, Shuming Chen, Eric Meggers
Tags
α-amination
iron catalysis
amino acids
sustainable chemistry
carboxylic acids
Boc protecting group
Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny