logo
ResearchBunny Logo
Abstract
This paper reports a highly stereocontrolled, iron-catalyzed direct α-amination of carboxylic acid feedstock molecules, providing a single-step synthesis of high-value *N*-Boc-protected α-monosubstituted and α,α-disubstituted α-amino acids. The method uses abundant carboxylic acids, sustainable and earth-abundant iron catalysis, and the commonly used Boc protecting group, making it highly efficient and environmentally friendly.
Publisher
Nature Synthesis
Published On
Jul 01, 2023
Authors
Chen-Xi Ye, Drew R. Dansby, Shuming Chen, Eric Meggers
Tags
α-amination
iron catalysis
amino acids
sustainable chemistry
carboxylic acids
Boc protecting group

Related Publications

Explore these studies to deepen your understanding of the subject.

Iridium-catalyzed enantioselective synthesis of chiral γ-amino alcohols and intermediates of (S)-duloxetine, (R)-fluoxetine, and (R)-atomoxetine
Chemistry

Iridium-catalyzed enantioselective synthesis of chiral γ-amino alcohols and intermediates of (S)-duloxetine, (R)-fluoxetine, and (R)-atomoxetine

C. Liu, L. Zhang, et al.

Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles
Chemistry

Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles

M. Wang, C. Wang, et al.

Multipartite entanglement of billions of motional atoms heralded by single photon
Physics

Multipartite entanglement of billions of motional atoms heralded by single photon

H. Li, J. Dou, et al.

Discovery of *Trypanosoma brucei* inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides
Chemistry

Discovery of *Trypanosoma brucei* inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides

B. S. Mantilla, J. S. White, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs—just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny