Medicine and Health

Exosome-coated oxygen nanobubble-laden hydrogel augments intracellular delivery of exosomes for enhanced wound healing

X. Han, C. Saengow, et al.

Discover a groundbreaking strategy to enhance wound healing, developed by Xiaoxue Han, Chaimongkol Saengow, Leah Ju, Wen Ren, Randy H. Ewoldt, and Joseph Irudayaraj. This innovative approach combines oxygen nanobubbles coated with exosomes from adipose tissue-derived stem cells, embedded in a self-healing hydrogel, demonstrating remarkable improvements in wound recovery.

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Abstract

This research introduces a novel strategy to enhance wound healing by addressing inadequate angiogenesis, inflammation, and chronic hypoxia. The approach involves coating oxygen nanobubbles with exosomes derived from adipose tissue-derived stem cells (ADSCs) and embedding them within a self-healing polyvinyl alcohol/gelatin hydrogel. This multifunctional hydrogel alleviates hypoxia, delivers exosomes efficiently, promotes hemostasis, and reduces inflammation. In a rat model, the hydrogel demonstrated accelerated wound healing, increased angiogenesis, and reduced inflammation.

Publisher

Nature Communications

Published On

Apr 23, 2024

Authors

Xiaoxue Han, Chaimongkol Saengow, Leah Ju, Wen Ren, Randy H. Ewoldt, Joseph Irudayaraj

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