Biology

Evolution of T cells in the cancer-resistant naked mole-rat

T. D. Lin, N. D. Rubinstein, et al.

Discover the secrets behind the remarkable longevity and cancer resistance of naked mole-rats, as revealed by cutting-edge research from Tzuhua D. Lin and colleagues. This study uncovers unique T-cell subsets and adaptive immune features that may hold the key to understanding these fascinating creatures.

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Playback language: English

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Abstract

Naked mole-rats (NMRs) exhibit extreme longevity and cancer resistance, prompting investigation into their unique immune system. This study uses single-cell transcriptomics and TCR sequencing to characterize NMR T-cell subsets, revealing a large circulating population of γδT cells, a dominant clonotype within a cytotoxic γδT-cell subset, and modest clonotypic diversity in conventional CD8 αβT cells. Smaller NMR thymuses compared to mice suggest adaptation under relaxed intracellular pathogenic pressure, potentially favoring cancer resistance and longevity.

Publisher

Nature Communications

Published On

Apr 11, 2024

Authors

Tzuhua D. Lin, Nimrod D. Rubinstein, Nicole L. Fong, Megan Smith, Wendy Craft, Baby Martin-McNulty, Rebecca Perry, Martha A. Delaney, Margaret A. Roy, Rochelle Buffenstein

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