BiologyNature Chemical Biology
Enriching productive mutational paths accelerates enzyme evolution
D. Patsch, T. Schwander, et al.
Discover how targeted removal of destabilizing mutations can turbocharge enzyme evolution! This groundbreaking research by David Patsch and colleagues showcases a Kemp eliminase variant that achieved an astounding >10⁸-fold rate acceleration in just five evolution rounds, revealing a rich fitness landscape within a single protein scaffold.
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