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Abstract
This study investigates the potential of using cubosomes, a type of nanostructured lipid carrier, to enhance the activity of polymyxin B (PMB) against Gram-negative bacteria. The researchers explored the interaction between PMB-loaded cubosomes and bacterial membranes using various techniques, including quartz crystal microbalance with dissipation monitoring (QCM-D), neutron reflectometry (NR), and confocal microscopy. The results suggest that cubosomes can facilitate PMB delivery to bacterial membranes, leading to improved antimicrobial efficacy.
Publisher
Nature Communications
Published On
Jan 17, 2022
Authors
Xiaohui Lai, Matthew L. Hills, Yujie Du, Shu-Hong Chen, A. P. L. B., C.-M. Wang, Peter J. Bergen, Jian-Hua Jiang, Hong-Yuan Hu, Jian Shi, Benjamin W. Muir, Jian Li, Hsin-Hui Shen
Tags
cubosomes
polymyxin B
Gram-negative bacteria
nanostructured lipid carriers
antimicrobial efficacy

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