logo
ResearchBunny Logo
Abstract
Antimicrobial resistance is a significant threat. This paper details the synthesis of fluorescent vancomycin probes, modified with an azide substituent, which undergo a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction with various alkynes. Three probes retaining antibacterial activity were synthesized and shown to effectively detect Gram-positive bacteria and measure Gram-negative outer membrane permeabilization. These probes are valuable tools for infection detection and antibiotic development.
Publisher
Communications Biology
Published On
Apr 14, 2023
Authors
Bing Zhang, Wanida Phetsang, M. Rhia L. Stone, Sanjaya Kc, Mark S. Butler, Matthew A. Cooper, Alysha G. Elliott, Urszula Łapińska, Margaritis Voliotis, Krasimira Tsaneva-Atanasova, Stefano Pagliara, Mark A. T. Blaskovich
Tags
antimicrobial resistance
fluorescent probes
vancomycin
Gram-positive bacteria
antibiotic development
infection detection
CuAAC reaction

Related Publications

Explore these studies to deepen your understanding of the subject.

Effects of positive and negative social feedback on motivation, evaluative learning, and socio-emotional processing
Psychology

Effects of positive and negative social feedback on motivation, evaluative learning, and socio-emotional processing

A. Sobczak and N. Bunzeck

Enhancing Polymyxin B Activity against Gram-Negative Bacteria Using Cubosomes
Medicine and Health

Enhancing Polymyxin B Activity against Gram-Negative Bacteria Using Cubosomes

X. Lai, M. L. Hills, et al.

Fast reduction of Atlantic SST threatens Europe-wide gross primary productivity under positive and negative CO2 emissions
Environmental Studies and Forestry

Fast reduction of Atlantic SST threatens Europe-wide gross primary productivity under positive and negative CO2 emissions

Y. Yang, J. Shin, et al.

Antiseptic quaternary ammonium compound tolerance by gram-negative bacteria can be rapidly detected using an impermeant fluorescent dye-based assay
Medicine and Health

Antiseptic quaternary ammonium compound tolerance by gram-negative bacteria can be rapidly detected using an impermeant fluorescent dye-based assay

B. S. J. Gregorchuk, S. L. Reimer, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs—just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny