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Synthesis of vancomycin fluorescent probes that retain antimicrobial activity, identify Gram-positive bacteria, and detect Gram-negative outer membrane damage

Medicine and Health

Synthesis of vancomycin fluorescent probes that retain antimicrobial activity, identify Gram-positive bacteria, and detect Gram-negative outer membrane damage

B. Zhang, W. Phetsang, et al.

Explore the groundbreaking work of authors Bing Zhang, Wanida Phetsang, and their team as they unveil fluorescent vancomycin probes that not only retain antibacterial activity but also help detect Gram-positive bacteria and assess Gram-negative outer membrane permeabilization. These innovative tools could make a significant impact on infection detection and antibiotic development.

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Playback language: English
Abstract
Antimicrobial resistance is a significant threat. This paper details the synthesis of fluorescent vancomycin probes, modified with an azide substituent, which undergo a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction with various alkynes. Three probes retaining antibacterial activity were synthesized and shown to effectively detect Gram-positive bacteria and measure Gram-negative outer membrane permeabilization. These probes are valuable tools for infection detection and antibiotic development.
Publisher
Communications Biology
Published On
Apr 14, 2023
Authors
Bing Zhang, Wanida Phetsang, M. Rhia L. Stone, Sanjaya Kc, Mark S. Butler, Matthew A. Cooper, Alysha G. Elliott, Urszula Łapińska, Margaritis Voliotis, Krasimira Tsaneva-Atanasova, Stefano Pagliara, Mark A. T. Blaskovich
Tags
antimicrobial resistance
fluorescent probes
vancomycin
Gram-positive bacteria
antibiotic development
infection detection
CuAAC reaction

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