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Abstract
Small RNAs (miRNAs or siRNAs) are effective tools for cancer therapy, but existing carriers have limitations. Plant-derived vesicles (PDVs) offer promise as RNA carriers, but issues like insufficient loading and scalability remain. This study developed a hybrid exosomal polymeric system (HEXPO) using watermelon PDVs and a dendrimer bound to miRNA146 mimic. In vivo experiments demonstrated therapeutic efficacy and revealed miR146a's anti-angiogenic activity.
Publisher
npj Precision Oncology
Published On
Apr 06, 2024
Authors
Sara Corvigno, Yuan Liu, Emine Bayraktar, Elaine Stur, Nazende Nur Bayram, Adrian Lankenau Ahumada, Supriya Nagaraju, Cristian Rodriguez-Aguayo, Hu Chen, Thanh Chung Vu, Yunfei Wen, Han Liang, Li Zhao, Sanghoon Lee, Gabriel Lopez-Berestein, Anil K. Sood
Tags
small RNAs
cancer therapy
plant-derived vesicles
exosomal system
miRNA146 mimic
therapeutic efficacy
anti-angiogenic activity

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