Medicine and Health

Emergence and spread of a SARS-CoV-2 lineage A variant (A.23.1) with altered spike protein in Uganda

D. L. Bugembe, M. V. T. Phan, et al.

Explore the fascinating genomic surveillance study of SARS-CoV-2 in Uganda conducted by a team of experts, revealing the rise of the lineage A.23.1, which might impact vaccine efficacy due to its spike protein changes resembling Variants of Concern. Join the conversation spearheaded by Daniel Lule Bugembe and colleagues!

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Abstract

This study reports on genomic surveillance of SARS-CoV-2 in Uganda from March 2020 to January 2021. Phylogenetic analysis revealed the emergence and spread of lineage A.23.1, which became dominant by January 2021. A.23.1 contains spike protein changes similar to Variants of Concern (VOCs), including alterations in the furin cleavage site and N-terminal domain. Changes were also observed in non-spike proteins (nsp6, ORF8, ORF9). While the clinical impact remains unclear and A.23.1 isn't designated a VOC, the authors advise careful monitoring and assessment of its impact on vaccine efficacy.

Publisher

Nature Microbiology

Published On

Jun 23, 2021

Authors

Daniel Lule Bugembe, My V. T. Phan, Isaac Ssewanyana, Patrick Semanda, Hellen Nansumba, Beatrice Dhaala, Susan Nabadda, Áine Niamh O’Toole, Andrew Rambaut, Pontiano Kaleebu, Matthew Cotten

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