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Abstract
This study investigated the anti-influenza capacity of several Iranian Scutellaria species and identified active compounds from the most potent species. Methanol fraction of S. pinnatifida subsp. viridis showed the highest flavonoid content and best activity against influenza A virus, reducing the virus titer by 5 logs without cytotoxicity. Kaempferol-3-O-glucoside, quercetin-3-O-glucoside, apigenin-4′-methoxy-7-O-glucoside, luteolin, and luteolin-7-O-glucoside were identified. S. pinnatifida subsp. viridis is a source of flavonoids with anti-influenza activity, and S. tomentosa is a candidate for further studies.
Publisher
Iranian Journal of Basic Medical Sciences
Published On
Jun 21, 2023
Authors
Mostafa Pirali Hamedani, Mahtab Ahmad Kashi, Saied Goodarzi, Hadiseh Shokouhi, Mahdi Shafiee Ardestani, Abbas Hadjiakhoondi, Morteza Pirali Hamedani, Mohammad Hosein Ghahremani, Parvaneh Mehrbod, Zahra Tofighi
Tags
Scutellaria
anti-influenza
flavonoids
S. pinnatifida
virus reduction
Iranian medicinal plants
active compounds

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