Biology

Elucidation of flavonoids from potent Iranian Scutellaria species against Influenza A (H1N1) virus

M. P. Hamedani, M. A. Kashi, et al.

This study reveals the powerful anti-influenza properties of Iranian Scutellaria species, particularly S. pinnatifida subsp. viridis, which not only showed a remarkable reduction in influenza A virus titer without cytotoxicity but also boasts a rich flavonoid profile. Conducted by an expert team including Mostafa Pirali Hamedani and Mahtab Ahmad Kashi, this research highlights potential new avenues for influenza treatment.

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Abstract

This study investigated the anti-influenza capacity of several Iranian Scutellaria species and identified active compounds from the most potent species. Methanol fraction of S. pinnatifida subsp. viridis showed the highest flavonoid content and best activity against influenza A virus, reducing the virus titer by 5 logs without cytotoxicity. Kaempferol-3-O-glucoside, quercetin-3-O-glucoside, apigenin-4′-methoxy-7-O-glucoside, luteolin, and luteolin-7-O-glucoside were identified. S. pinnatifida subsp. viridis is a source of flavonoids with anti-influenza activity, and S. tomentosa is a candidate for further studies.

Publisher

Iranian Journal of Basic Medical Sciences

Published On

Jun 21, 2023

Authors

Mostafa Pirali Hamedani, Mahtab Ahmad Kashi, Saied Goodarzi, Hadiseh Shokouhi, Mahdi Shafiee Ardestani, Abbas Hadjiakhoondi, Morteza Pirali Hamedani, Mohammad Hosein Ghahremani, Parvaneh Mehrbod, Zahra Tofighi

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