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Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection

Medicine and Health

Electrophysiological engineering of heart-derived cells with calcium-dependent potassium channels improves cell therapy efficacy for cardioprotection

P. Vigneault, S. Parent, et al.

This innovative research by Patrick Vigneault and colleagues explores how calcium-activated potassium channels could revolutionize cell therapy for heart diseases. The study highlights the potent role of KCa3.1 in enhancing heart function and cell growth, offering promising avenues for cardiac protection and regeneration.

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Playback language: English
Abstract
This study investigates the role of calcium-activated potassium (KCa) channels in human heart explant-derived cell (EDC) physiology and therapeutic potential. It finds that KCa3.1 channels are exclusively expressed in therapeutically bioactive EDC subfractions, maintaining a polarized resting potential. Gene transfer of *KCNN4* (encoding KCa3.1) leads to membrane hyperpolarization, increased intracellular calcium, boosted cell proliferation, and increased production of pro-healing cytokines/nanoparticles. In a murine model of ischemic cardiomyopathy, *KCNN4*-overexpressing EDCs significantly improved cardiac function, viable myocardium, and neovascularization. This suggests electrophysiological engineering as a valuable strategy to enhance cell therapy efficacy for cardioprotection.
Publisher
Nature Communications
Published On
Aug 16, 2021
Authors
Patrick Vigneault, Sandrine Parent, Pushpinder Kanda, Connor Michie, Darryl R. Davis, Stanley Nattel
Tags
calcium-activated potassium channels
KCa3.1
therapeutic potential
cell therapy
ischemic cardiomyopathy
cardiac function
neovascularization

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