Chemistry

Electrochemical Insertion of Ammonia into Cyclic Alkenes for the Synthesis of Aromatic N-Heterocycles

S.i. and X.c.

Discover a groundbreaking electrochemical method developed by S.I. and X.C. for the direct insertion of ammonia into cyclic alkenes, enabling the synthesis of various aromatic N-heterocycles with remarkable efficiency and versatility.

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Abstract

This paper reports a novel electrochemical method for the direct insertion of ammonia into cyclic alkenes to synthesize diverse aromatic N-heterocycles. The method utilizes electrochemical hydrogen evolution, avoiding the need for external oxidants and achieving up to 99.2% theoretical atom economy. This approach offers advantages including tolerance of oxidation-labile functional groups and a broad substrate scope.

Publisher

Nature Communications

Published On

Oct 26, 2022

Authors

S.I., X.C.

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