EGCG Attenuates CA1 Neuronal Death by Regulating GPx1, NF-κB | ResearchBunny

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Abstract

This study investigated the neuroprotective effects of epigallocatechin-3-gallate (EGCG) on CA1 neuronal death following status epilepticus (SE) in rats. EGCG attenuated SE-induced CA1 neuronal death and mitochondrial hyperfusion by upregulating glutathione peroxidase-1 (GPx1), preserving ERK1/2-DRP1-mediated mitochondrial fission, and inhibiting NF-κB S536 phosphorylation. ERK1/2 inhibition blocked EGCG's neuroprotective and mitochondrial effects, suggesting ERK1/2 activation is crucial for EGCG's mechanism.

Publisher

Antioxidants

Published On

Apr 20, 2023

Authors

Andrey V Kozlov, Sabzali Javadov, Natascha Sommer, Ji-Eun Kim, Tae-Hyun Kim, Tae-Cheon Kang

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