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Efficacy of Olaparib in Treatment-Refractory, Metastatic Breast Cancer with Uncommon Somatic BRCA Mutations Detected in Circulating Tumor DNA

Medicine and Health

Efficacy of Olaparib in Treatment-Refractory, Metastatic Breast Cancer with Uncommon Somatic BRCA Mutations Detected in Circulating Tumor DNA

J. Yoon, J. Ahn, et al.

This case report by Jung-Ki Yoon and colleagues explores the impact of a rare somatic BRCA1 mutation on metastatic breast cancer treatment. After standard therapies failed, a remarkable response to olaparib was observed, shedding light on its potential for patients with unusual BRCA mutations. However, the emergence of resistance highlights the complexities of treatment strategies. Discover the insights from this intriguing research!

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