This randomized controlled trial (RCT) investigated the efficacy of a digital multimodal weight loss intervention program delivered via a smartphone app on body weight in adults with obesity. 168 adults (BMI 30.0-40.0 kg/m²) were randomized into two groups: ADHOC (app-based intervention from baseline for 12 weeks plus 12 weeks follow-up) and EXPECT (app-based intervention after a 12-week waiting period). The ADHOC group showed a significant weight loss of 3.2 kg (3.2%) after 12 weeks compared to 0.4 kg (0.3%) in the EXPECT group (p<0.001). Weight maintenance was observed in the ADHOC group at 24 weeks. Time spent using the app was associated with weight reduction. The app-based program, a Digital Health Application (DiHA) covered by German health insurance, proved moderately effective for weight loss in individuals with obesity.

Kathrin Gemesi, Stefanie Winkler, Susanne Schmidt-Tesch, Florian Schederecker, Hans Hauner, Christina Holzapfel