Medicine and Health

Effects of diets on risks of cancer and the mediating role of metabolites

Y. Fan, C. Hu, et al.

This groundbreaking research conducted by Yi Fan, Chanchan Hu, Xiaoxu Xie, Yanfeng Weng, Chen Chen, Zhakoun Wang, Xueqiong He, Dongxia Jiang, Shaodan Huang, Zhijian Hu, and Fengqing Liu reveals significant negative associations between the Mediterranean and MIND diets and cancer risks. The study uncovers 10 key metabolites that mediate this relationship, shedding light on the intricate connections between diet, metabolites, and cancer development.

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Abstract

This study investigates the associations between adherence to Mediterranean diet (MedDiet) or MIND diet and overall/specific cancer risks, exploring the mediating effects of metabolites using UK Biobank data. Results show significant negative associations of both diets with overall and several specific cancers. A sequential analysis identified 10 metabolites associated with cancer risk, mediating the relationship between diet and cancer risk. These findings highlight the complex interplay between diet, metabolites, and cancer development.

Publisher

Nature Communications

Published On

Jul 13, 2024

Authors

Yi Fan, Chanchan Hu, Xiaoxu Xie, Yanfeng Weng, Chen Chen, Zhakoun Wang, Xueqiong He, Dongxia Jiang, Shaodan Huang, Zhijian Hu, Fengqing Liu

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