Medicine and Health

Effectiveness of a third BNT162b2 mRNA COVID-19 vaccination during pregnancy: a national observational study in Israel

J. Guedalia, M. Lipschuetz, et al.

This national cohort study from Israel reveals the impressive effectiveness of a third BNT162b2 mRNA COVID-19 vaccine dose in protecting pregnant women against COVID-19-related hospitalizations during the Delta and Omicron variants. The findings underscore the enhanced protection, especially against severe disease, provided by this additional dose, conducted by a team of expert researchers.

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Abstract

This national, population-based, historical cohort study in Israel analyzed the effectiveness of a third BNT162b2 mRNA COVID-19 vaccine dose in preventing COVID-19-related hospitalizations during pregnancy during Delta and Omicron waves. The third dose showed high effectiveness against overall hospitalizations (92% during Delta, 48% during Omicron) and significant/severe disease. The study highlights the enhanced protection offered by a third dose, particularly against severe outcomes.

Publisher

Nature Communications

Published On

Nov 15, 2022

Authors

Joshua Guedalia, Michal Lipschuetz, Ronit Calderon-Margalit, Sarah M. Cohen, Debra Goldman-Wohl, Tali Kaminer, Eli Meuli, Galit Shefer, Yishai Sompolinsky, Asnat Walfisch, Simcha Yagel, Ofer Beharier

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