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Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

Medicine and Health

Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system

G. Chevalier, E. Siopi, et al.

This groundbreaking research explores how gut microbiota influences depressive-like behaviors in mice under unpredictable chronic stress. The findings reveal that these behaviors can be transferred via fecal microbiota transplantation, linking chronic stress, gut health, and the endocannabinoid system. This alarming connection was uncovered by a talented team of researchers including Grégoire Chevalier, Eleni Siopi, and others at the prestigious Institut Pasteur.

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Playback language: English
Abstract
This study investigates the link between gut microbiota and depressive-like behaviors in mice using unpredictable chronic mild stress (UCMS). UCMS induced depressive behaviors, transferable via fecal microbiota transplantation (FMT) to naive recipients. This transfer was associated with decreased endocannabinoid (eCB) signaling due to lower fatty acid precursors. Enhancing central eCB signaling or *Lactobacilli* supplementation alleviated these effects, suggesting a mechanistic link between chronic stress, gut microbiota, and depressive behaviors mediated by the eCB system.
Publisher
Nature Communications
Published On
Dec 11, 2020
Authors
Grégoire Chevalier, Eleni Siopi, Laure Guenin-Macé, Maud Pascal, Thomas Laval, Aline Rifflet, Ivo Gomperts Boneca, Caroline Demangel, Benoit Colsch, Alain Pruvost, Emeline Chu-Van, Aurélie Messager, François Leulier, Gabriel Lepousez, Gérard Eberl, Pierre-Marie Lledo
Tags
gut microbiota
depression
chronic stress
endocannabinoid system
fecal microbiota transplantation
mice
Lactobacilli

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