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Discovery, total syntheses and potent anti-inflammatory activity of pyrrolinone-fused benzoazepine alkaloids Asperazepanones A and B from *Aspergillus candidus*

Medicine and Health

Discovery, total syntheses and potent anti-inflammatory activity of pyrrolinone-fused benzoazepine alkaloids Asperazepanones A and B from *Aspergillus candidus*

L. Xu, F. Guo, et al.

Discover the groundbreaking findings of Li Xu, Feng-Wei Guo, Xue-Qing Zhang, Tian-Yi Zhou, Chao-Jie Wang, Mei-Yan Wei, Yu-Cheng Gu, Chang-Yun Wang, and Chang-Lun Shao, who isolated two novel pyrrolinone-fused benzoazepine alkaloids from a coral-derived fungus. With potential anti-inflammatory properties, these compounds could lead to new therapeutic avenues.

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Playback language: English
Abstract
Two pyrrolinone-fused benzoazepine alkaloids, (+)-asperazepanones A (1) and B (2), were isolated from the coral-derived *Aspergillus candidus* fungus. Their structures and absolute configurations were elucidated. Total syntheses of (±)-1 and (±)-2 were achieved. (+)-2 showed potent inhibitory activity against NO production and LPS-induced expression of TNF-α and IL-6, suggesting its potential as an anti-inflammatory drug lead.
Publisher
Communications Chemistry
Published On
Jul 06, 2022
Authors
Li Xu, Feng-Wei Guo, Xue-Qing Zhang, Tian-Yi Zhou, Chao-Jie Wang, Mei-Yan Wei, Yu-Cheng Gu, Chang-Yun Wang, Chang-Lun Shao
Tags
pyrrolinone-fused
benzoazepine
anti-inflammatory
Aspergillus candidus
alkaloids
total synthesis
NO production

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