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Discovery of *Trypanosoma brucei* inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides

Chemistry

Discovery of *Trypanosoma brucei* inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides

B. S. Mantilla, J. S. White, et al.

Discover the groundbreaking research conducted by Brian S. Mantilla and colleagues at the University of Leeds and the University of St Andrews, who developed a unified synthesis of sulfonyl fluorides. Their innovative photoredox-catalyzed approach led to the identification of compounds with remarkable anti-trypanosomal activity, revealing new therapeutic potential against *Trypanosoma brucei*.

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Playback language: English
Abstract
This research paper describes the development of a unified synthesis of diverse sulfonyl fluorides using photoredox-catalyzed dehydrogenative couplings. A library of 32 probes was created and screened against *Trypanosoma brucei*, identifying four with sub-micromolar anti-trypanosomal activity. Chemical proteomics revealed that the anti-trypanosomal activity likely arises from covalent modification of multiple protein targets.
Publisher
Communications Chemistry
Published On
Oct 19, 2024
Authors
Brian S. Mantilla, Jack S. White, William R. T. Mosedale, Andrew Gomm, Adam Nelson, Terry K. Smith, Megan H. Wright
Tags
sulfonyl fluorides
photoredox-catalyzed
anti-trypanosomal
chemical proteomics
dehydrogenative couplings
Trypanosoma brucei
covalent modification

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