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Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia
Medicine and HealthJournal of Medicinal Chemistry

Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia

M. E. Layton, J. C. Kern, et al.

Discover how the inhibition of Phosphodiesterase 10A (PDE10A) could revolutionize schizophrenia treatment by normalizing striatal activity. This exciting research conducted by Mark E Layton and colleagues unveils MK-8189, a powerful PDE10A inhibitor currently undergoing Phase 2b clinical development.... show more
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