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Dietary prebiotics promote intestinal *Prevotella* in association with a low-responding phenotype in a murine oxazolone-induced model of atopic dermatitis

Veterinary Science

Dietary prebiotics promote intestinal *Prevotella* in association with a low-responding phenotype in a murine oxazolone-induced model of atopic dermatitis

A. Laigaard, L. Krych, et al.

This study, conducted by Ann Laigaard and colleagues, reveals how xylooligosaccharide (XOS) can significantly reduce dermatitis responses and enhance gut microbiota composition in a murine model. With better gut health linked to higher *Prevotella* spp. levels, this research opens doors for innovative microbiota-targeted therapies in allergy management.

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Playback language: English
Abstract
This study investigated the effects of the prebiotic xylooligosaccharide (XOS) on gut microbiota and ear inflammation in a murine model of oxazolone-induced atopic dermatitis. Mice fed an XOS-supplemented diet showed significantly fewer high responders to dermatitis compared to controls. XOS-fed mice also exhibited higher abundances of *Prevotella* spp. in their gut microbiota. A strong association between the low-responding phenotype and high *Prevotella* abundance suggests an anti-inflammatory role for this bacterium in allergic sensitization, highlighting it as a potential target for microbiota-directed therapies.
Publisher
Scientific Reports
Published On
Dec 03, 2020
Authors
Ann Laigaard, Lukasz Krych, Line F. Zachariassen, Lea Ellegaard-Jensen, Dennis S. Nielsen, Axel K. Hansen, Camilla H. F. Hansen
Tags
xylooligosaccharide
gut microbiota
atopic dermatitis
Prevotella
anti-inflammatory
murine model
allergic sensitization

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