Medicine and Health

Development of graphitic carbon nitride quantum dots-based oxygen self-sufficient platforms for enhanced corneal crosslinking

M. Yang, T. Chen, et al.

Discover the groundbreaking advancement in accelerated corneal crosslinking (A-CXL) using biocompatible graphitic carbon nitride quantum dots. This study reveals how these innovative materials enhance oxygen generation and corneal strengthening, surpassing the standard protocols. Join the authors Mei Yang, Tingting Chen, Xin Chen, and their team in exploring this promising technology for corneal ectasias.

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Abstract

Accelerated corneal crosslinking (A-CXL) is hampered by rapid stromal oxygen depletion at higher UVA intensities. This study developed biocompatible graphitic carbon nitride (g-C3N4) quantum dots (QDs) and riboflavin/g-C3N4 QDs composites (RF@g-C3N4 QDs) as oxygen self-sufficient platforms for A-CXL. Both showed excellent photocatalytic oxygen generation, high ROS yield, and biosafety. A-CXL using g-C3N4 QDs or RF@g-C3N4 QDs was superior to the standard RF A-CXL protocol, indicating enhanced corneal strengthening. This suggests potential application of g-C3N4 QDs in A-CXL for corneal ectasias.

Publisher

Nature Communications

Published On

Jun 29, 2024

Authors

Mei Yang, Tingting Chen, Xin Chen, Hongxian Pan, Guoli Zhao, Zhongxing Chen, Nan Zhao, Qianfang Ye, Ming Chen, Shenrong Zhang, Rongrong Gao, Keith M. Meek, Sally Hayes, Xiaowei Ma, Xin Li, Yue Wu, Yiming Zhang, Na Kong, Wei Tao, Xingtao Zhou, Jinhai Huang

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