Veterinary ScienceScientific Reports

Determinants of vitamin D status in Kenyan calves

R. Callaby, E. Hurst, et al.

This study explores the intriguing interplay between host and environmental factors influencing vitamin D status in Kenyan calves, revealing fascinating insights from a genome-wide association study. Notably, the research found that neonatal vitamin D levels are not predictors of infectious diseases or mortality over the first year. This research was conducted by Rebecca Callaby, Emma Hurst, Ian Handel, Phil Toye, Barend M. de C. Bronsvoort, and Richard J. Mellanby.... show more

General Summary Metrics

Abstract

Vitamin D plays a critical role in calcium homeostasis and skeletal health. Vitamin D status has been linked to numerous non-skeletal outcomes across species. This study aimed to define host and environmental factors associated with vitamin D status in 527 East African Shorthorn Zebu calves from Western Kenya (IDEAL cohort), and to explore whether serum 25-hydroxyvitamin D (25(OH)D) at 7 days of age predicts health outcomes over 12 months. A genome-wide association study indicated that both dietary- and endogenously derived vitamin D metabolites are under polygenic control in African calves. Neonatal vitamin D status was not predictive of subsequent infectious disease events or mortality during the following year.

Publisher

Scientific Reports

Published On

Nov 25, 2020

Authors

Rebecca Callaby, Emma Hurst, Ian Handel, Phil Toye, Barend M. de C. Bronsvoort, Richard J. Mellanby

DOI

https://doi.org/10.1038/s41598-020-77209-5

Explore these studies to deepen your understanding

Adjacent work that informs or extends this paper's methodology and findings.

Medicine and Health

Vitamin D is involved in the effects of the intestinal flora and its related metabolite TMAO on perirenal fat and kidneys in mice with DKD

X. Zheng, Y. Huang, et al.

Health and Fitness

The effect of daily intake of vitamin D-fortified yogurt drink, with and without added calcium, on serum adiponectin and sirtuins 1 and 6 in adult subjects with type 2 diabetes

B. Nikooyeh, B. W. Hollis, et al.

Medicine and Health

Effects of vitamin D in pregnancy on maternal and offspring health-related outcomes: An umbrella review of systematic review and meta-analyses

M. Chien, C. Huang, et al.

Social Work

The production of social science research in Nigeria: status and systemic determinants

A. Egbetokun, A. Olofinyehun, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 22+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny