Veterinary ScienceScientific Reports

Determinants of vitamin D status in Kenyan calves

R. Callaby, E. Hurst, et al.

This study explores the intriguing interplay between host and environmental factors influencing vitamin D status in Kenyan calves, revealing fascinating insights from a genome-wide association study. Notably, the research found that neonatal vitamin D levels are not predictors of infectious diseases or mortality over the first year. This research was conducted by Rebecca Callaby, Emma Hurst, Ian Handel, Phil Toye, Barend M. de C. Bronsvoort, and Richard J. Mellanby.... show more

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Abstract

Vitamin D plays a critical role in calcium homeostasis and skeletal health. Vitamin D status has been linked to numerous non-skeletal outcomes across species. This study aimed to define host and environmental factors associated with vitamin D status in 527 East African Shorthorn Zebu calves from Western Kenya (IDEAL cohort), and to explore whether serum 25-hydroxyvitamin D (25(OH)D) at 7 days of age predicts health outcomes over 12 months. A genome-wide association study indicated that both dietary- and endogenously derived vitamin D metabolites are under polygenic control in African calves. Neonatal vitamin D status was not predictive of subsequent infectious disease events or mortality during the following year.

Publisher

Scientific Reports

Published On

Nov 25, 2020

Authors

Rebecca Callaby, Emma Hurst, Ian Handel, Phil Toye, Barend M. de C. Bronsvoort, Richard J. Mellanby

DOI

https://doi.org/10.1038/s41598-020-77209-5

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