Medicine and Health

Detection of SARS-CoV-2 viral proteins and genomic sequences in human brainstem nuclei

A. Emmi, S. Rizzo, et al.

Explore the intriguing connections between COVID-19 and the nervous system in this study revealing neuroinvasive potential of SARS-CoV-2, conducted by Aron Emmi, Stefania Rizzo, Luisa Barzon, and others. Discover how brainstem inflammation could influence neurodegeneration!

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Playback language: English

Index

Abstract

Neurological manifestations are common in COVID-19. This study assessed neuropathological alterations in 24 COVID-19 patients and 18 matched controls. SARS-CoV-2 immunoreactive neurons were detected in the brainstem of five COVID-19 subjects, with viral RNA also detected. Increased reactive microglia was observed in affected brainstem regions. The results support SARS-CoV-2's neuroinvasive potential and brainstem inflammation's role in COVID-19, suggesting further investigation into implications for neurodegeneration.

Publisher

npj Parkinson's Disease

Published On

Feb 13, 2023

Authors

Aron Emmi, Stefania Rizzo, Luisa Barzon, Michele Sandre, Elisa Carturan, Alessandro Sinigaglia, Silvia Riccetti, Mila Della Barbera, Rafael Boscolo-Berto, Patrizia Cocco, Veronica Macchi, Angelo Antonini, Monica De Gaspari, Cristina Basso, Raffaele De Caro, Andrea Porzionato

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