Chemistry

Design of a gold clustering site in an engineered apo-ferritin cage

C. Lu, B. Maity, et al.

Discover the innovative engineering behind a unique gold clustering site within the apo-ferritin cage, capable of holding up to 12 gold atoms! This groundbreaking research, conducted by Chenlin Lu, Basudev Maity, Xue Peng, Nozomi Ito, Satoshi Abe, Xiang Sheng, Takafumi Ueno, and Diannan Lu, unveils the intricate role of amino acids in gold ion accumulation and cluster formation.

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Abstract

This research paper details the engineering and construction of a gold clustering site within the 4-fold symmetric axis channel of an apo-ferritin cage. Utilizing X-ray crystallography and quantum chemical calculations, the authors investigated the stepwise accumulation of gold ions, the formation of a multinuclear gold cluster, and the roles of key amino acid residues in this process. The study reveals a unique gold clustering site capable of accommodating up to 12 gold atoms, with the cluster's structure precisely tunable by varying the gold precursor concentration.

Publisher

Communications Chemistry

Published On

Mar 21, 2022

Authors

Chenlin Lu, Basudev Maity, Xue Peng, Nozomi Ito, Satoshi Abe, Xiang Sheng, Takafumi Ueno, Diannan Lu

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