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Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos

Biology

Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos

H. K. Lee, H. E. Smith, et al.

This groundbreaking study by Hye Kyung Lee and colleagues delves into the fidelity of cytosine base editor 4 (BE4) versus adenine base editor (ABE) in mouse embryos, revealing critical insights about genetic editing efficiency and precision.

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