This study investigated the association between central and general adiposity with albuminuria risk in 408,527 UK Biobank participants. Using ordinal logistic regression, researchers found that higher waist-to-hip ratio and BMI were independently associated with increased odds of higher urinary albumin-to-creatinine ratio (uACR) categories. While diabetes and related factors mediated a portion of these associations, the relationships remained significant even after adjusting for these mediators. The findings suggest strong adiposity-albuminuria links across various HbA1c levels.
Publisher
Springer Nature
Published On
Jul 16, 2020
Authors
Pengfei Zhu, Sarah Lewington, Richard Haynes, Jonathan Emberson, Martin J. Landray, David Cherney, Mark Woodward, Colin Baigent, William G. Herrington, Natalie Staplin
Tags
adiposity
albuminuria
BMI
waist-to-hip ratio
urinary albumin-to-creatinine ratio
diabetes
UK Biobank
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