Medicine and Health

Cross-sectional associations between central and general adiposity with albuminuria: observations from 400,000 people in UK Biobank

P. Zhu, S. Lewington, et al.

This compelling study by Pengfei Zhu and colleagues explores the intriguing link between body fat distribution and the risk of albuminuria among over 408,000 participants from the UK Biobank. The research highlights how an increased waist-to-hip ratio and BMI are associated with elevated urinary albumin levels, emphasizing vital connections related to diabetes and beyond.

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Abstract

This study investigated the association between central and general adiposity with albuminuria risk in 408,527 UK Biobank participants. Using ordinal logistic regression, researchers found that higher waist-to-hip ratio and BMI were independently associated with increased odds of higher urinary albumin-to-creatinine ratio (uACR) categories. While diabetes and related factors mediated a portion of these associations, the relationships remained significant even after adjusting for these mediators. The findings suggest strong adiposity-albuminuria links across various HbA1c levels.

Publisher

Springer Nature

Published On

Jul 16, 2020

Authors

Pengfei Zhu, Sarah Lewington, Richard Haynes, Jonathan Emberson, Martin J. Landray, David Cherney, Mark Woodward, Colin Baigent, William G. Herrington, Natalie Staplin

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