Medicine and Health

Cross-neutralization of Omicron BA.1 against BA.2 and BA.3 SARS-CoV-2

J. Zou, C. Kurhade, et al.

This study reveals the comprehensive cross-neutralization of Omicron sublineages BA.1, BA.2, and BA.3, shedding light on the varying effectiveness of neutralization in sera from BA.1-infected individuals. Conducted by experts from the University of Texas Medical Branch, this research underscores critical considerations for future COVID-19 vaccine strategies.

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Index

Abstract

The Omicron SARS-CoV-2 has several distinct sublineages, among which sublineline BA.1 was responsible for the initial Omicron surge and is now being replaced globally by BA.2, while BA.3 remains at low frequency. To understand cross-neutralization among these sublineages, the authors tested sera from BA.1-infected individuals against BA.2, BA.3, and USA/WA1-2020. BA.1-infected sera neutralized BA.1, BA.2, BA.3, and USA/WA1-2020 with geometric mean titers (GMTs) of 445, 107, 102, and 16, respectively, corresponding to 4.2-, 4.4-, and 28.4-fold lower neutralization against BA.2, BA.3, and USA/WA1-2020 relative to BA.1. These findings have implications for COVID-19 vaccine strategy.

Publisher

Nature Communications

Published On

May 26, 2022

Authors

Jing Zou, Chaitanya Kurhade, Hongjie Xia, Mingru Liu, Xuping Xie, Ping Ren, Pei-Yong Shi

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