BiologyNature Chemical Biology
CRISPR-Cas12a-mediated DNA clamping triggers target-strand cleavage
M. M. Naqvi, L. Lee, et al.
Dive into the fascinating world of CRISPR-Cas12a with this study by Mohsin M. Naqvi, Laura Lee, Oscar E. Torres Montaguth, Fiona M. Diffin, and Mark D. Szczelkun. Discover how target strand cleavage follows non-target strand cleavage, revealing intricate mechanisms of DNA unwinding and Cas12a-DNA interactions. This research uncovers critical insights into CRISPR's operation that could reshape genetic engineering.
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