logo
ResearchBunny Logo
Programmable CRISPR-Cas9 microneedle patch for long-term capture and real-time monitoring of universal cell-free DNA

Medicine and Health

Programmable CRISPR-Cas9 microneedle patch for long-term capture and real-time monitoring of universal cell-free DNA

B. Yang, J. Kong, et al.

Discover cutting-edge research by Bin Yang, Jilie Kong, and Xueen Fang on a groundbreaking wearable microneedle patch that enables long-term monitoring of universal cell-free DNA (cfDNA). This innovative approach harnesses CRISPR technology and reverse iontophoresis for efficient extraction and has shown promising results in monitoring vital health conditions.

00:00
00:00
Playback language: English
Abstract
This study presents a wearable microneedle patch for the extraction and in vivo long-term monitoring of universal cell-free DNA (cfDNA). The patch utilizes the synergistic effect of CRISPR-activated graphene biointerfaces and reverse iontophoresis for efficient extraction and real-time monitoring. The system successfully monitored cfDNA associated with Epstein-Barr virus, sepsis, and kidney transplantation in immunodeficient mouse models, demonstrating its feasibility and practicality for long-term in vivo monitoring of cfDNA and potential use in early disease screening and prognosis.
Publisher
NATURE COMMUNICATIONS
Published On
Jul 09, 2022
Authors
Bin Yang, Jilie Kong, Xueen Fang
Tags
wearable technology
microneedle patch
cell-free DNA
real-time monitoring
CRISPR
health monitoring
biomedical science

Related Publications

Explore these studies to deepen your understanding of the subject.

Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring
Medicine and Health

Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

K. Kim, I. S. Min, et al.

Wireless, battery-free, and real-time monitoring of water permeation across thin-film encapsulation
Engineering and Technology

Wireless, battery-free, and real-time monitoring of water permeation across thin-film encapsulation

M. Mariello, J. D. Rosenthal, et al.

Skin-integrated, biocompatible, and stretchable silicon microneedle electrode for long-term EMG monitoring in motion scenario
Engineering and Technology

Skin-integrated, biocompatible, and stretchable silicon microneedle electrode for long-term EMG monitoring in motion scenario

H. Ji, M. Wang, et al.

Novel Biomarkers for Early Detection of Acute Kidney Injury and Prediction of Long-Term Kidney Function Decline after Partial Nephrectomy
Medicine and Health

Novel Biomarkers for Early Detection of Acute Kidney Injury and Prediction of Long-Term Kidney Function Decline after Partial Nephrectomy

M. Allinovi, F. Sessa, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny