logo
ResearchBunny Logo
Controlled interconversion of macrocyclic atropisomers via defined intermediates

Chemistry

Controlled interconversion of macrocyclic atropisomers via defined intermediates

X. Sun, J. Bai, et al.

Discover the intriguing world of octamethyl cyclo[4](1,3-(4,6)-dimethylbenzene)[4]((4,6-benzene)(1,3-dicarboxylate) (OC-4) and its two stable atropisomers explored by researchers Xin Sun and colleagues. This study reveals the fascinating dynamics of structural conversion and guest interactions at varying temperatures, shedding light on the unique binding properties of these molecular architectures.

00:00
00:00
Playback language: English
Abstract
This paper presents a macrocycle, octamethyl cyclo[4](1,3-(4,6)-dimethylbenzene)[4]((4,6-benzene)(1,3-dicarboxylate) (OC-4), existing as two stable atropisomers (*C*<sub>2v</sub>-OC-4 and *C*<sub>4h</sub>-OC-4) at 298 K. Heating facilitates stepwise conversion of *C*<sub>4h</sub> to *C*<sub>2v</sub>-OC-4 via a *C<sub>s</sub>*-symmetric intermediate (*C<sub>s</sub>*-OC-4). Hydrolysis and esterification influence this conversion. *C*<sub>4h</sub>-OC-4, unlike *C*<sub>2v</sub>-OC-4, binds linear guests and fullerenes efficiently.
Publisher
Nature Communications
Published On
Aug 02, 2024
Authors
Xin Sun, Jin-Ku Bai, Yu-Dong Yang, Ke-Lin Zhu, Jia-Qi Liang, Xin-Yue Wang, Jun-Feng Xiang, Xiang Hao, Tong-Ling Liang, Ai-Jiao Guan, Ning-Ning Wu, Han-Yuan Gong
Tags
macrocycle
atropisomers
octamethyl cyclo[4]
structural conversion
guest binding
hydrolysis
esterification

Related Publications

Explore these studies to deepen your understanding of the subject.

Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs
Medicine and Health

Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs

R. Xiao, J. Li, et al.

Electro-assisted printing of soft hydrogels via controlled electrochemical reactions
Engineering and Technology

Electro-assisted printing of soft hydrogels via controlled electrochemical reactions

A. C. D. Silva, J. Wang, et al.

Investigation of intraocular pressure of the anterior chamber and vitreous cavity of porcine eyes via a novel method
Medicine and Health

Investigation of intraocular pressure of the anterior chamber and vitreous cavity of porcine eyes via a novel method

K. Nagae, H. Sawamura, et al.

Efficacy of primary series AZD1222 (ChAdOx1 nCoV-19) vaccination against SARS-CoV-2 variants of concern: Final analysis of a randomized, placebo-controlled, phase 1b/2 study in South African adults (COV005)
Medicine and Health

Efficacy of primary series AZD1222 (ChAdOx1 nCoV-19) vaccination against SARS-CoV-2 variants of concern: Final analysis of a randomized, placebo-controlled, phase 1b/2 study in South African adults (COV005)

A. L. Koen, A. Izu, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny