BiologyNature Communications
Computationally designed hyperactive Cas9 enzymes
P. D. Vos, G. Rossetti, et al.
This exciting research conducted by Pascal D. Vos, Giulia Rossetti, Jessica L. Mantegna, and others explores the engineering of hyperactive Cas9 enzymes, enhancing donor-independent editing activity. Using innovative computational design and yeast-based circuits, the study reveals significant improvements in CRISPR applications for broader genomic modifications.
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