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Abstract
The threat of coronavirus spillovers necessitates vaccines offering broader sarbecovirus protection. A single antigen, computationally designed using the receptor-binding domain (RBD) of the spike protein, elicited broad humoral responses against SARS-CoV-1, SARS-CoV-2, WIV16, and RaTG13 in mice, rabbits, and guinea pigs. Administered as DNA or MVA, this antigen provided protection against the Delta variant in ACE2-expressing mice primed with AZD1222. mRNA delivery further validated its broad immunogenicity, highlighting its potential to counteract zoonotic betacoronavirus threats.
Publisher
Nature Biomedical Engineering
Published On
Sep 25, 2023
Authors
Sneha Vishwanath, George William Carnell, Matteo Ferrari, Benedikt Asbach, Martina Billmeier, Charlotte George, Maria Suau Sans, Angalee Nadesalingam, Chloe Qingzhou Huang, Minna Paloniemi, Hazel Stewart, Andrew Chan, David Arthur Wells, Patrick Neckermann, David Peterhoff, Sebastian Einhauser, Diego Canton, Martin Mayora Neto, Ingo Jordan, Volker Sandig, Paul Tonks, Nigel Temperton, Simon Frost, Katharina Sohr, Maria Teresa Lluesma Ballesteros, Farzad Arbabi, Johannes Geiger, Christian Dohmen, Christian Plank, Rebecca Kinsley, Ralf Wagner, Jonathan Luke Heeney
Tags
coronavirus
vaccines
sarbecovirus
immunogenicity
Delta variant
spike protein
zoonotic diseases

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