Veterinary Science

A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses

S. Vishwanath, G. W. Carnell, et al.

This groundbreaking research reveals a single antigen designed from the receptor-binding domain of the spike protein that induces broad humoral responses against multiple coronavirus strains, including SARS-CoV-1 and SARS-CoV-2. Conducted by a team of experts including Sneha Vishwanath and George William Carnell, this study highlights the potential of innovative vaccines to tackle zoonotic threats, especially in light of the Delta variant.

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Abstract

The threat of coronavirus spillovers necessitates vaccines offering broader sarbecovirus protection. A single antigen, computationally designed using the receptor-binding domain (RBD) of the spike protein, elicited broad humoral responses against SARS-CoV-1, SARS-CoV-2, WIV16, and RaTG13 in mice, rabbits, and guinea pigs. Administered as DNA or MVA, this antigen provided protection against the Delta variant in ACE2-expressing mice primed with AZD1222. mRNA delivery further validated its broad immunogenicity, highlighting its potential to counteract zoonotic betacoronavirus threats.

Publisher

Nature Biomedical Engineering

Published On

Sep 25, 2023

Authors

Sneha Vishwanath, George William Carnell, Matteo Ferrari, Benedikt Asbach, Martina Billmeier, Charlotte George, Maria Suau Sans, Angalee Nadesalingam, Chloe Qingzhou Huang, Minna Paloniemi, Hazel Stewart, Andrew Chan, David Arthur Wells, Patrick Neckermann, David Peterhoff, Sebastian Einhauser, Diego Canton, Martin Mayora Neto, Ingo Jordan, Volker Sandig, Paul Tonks, Nigel Temperton, Simon Frost, Katharina Sohr, Maria Teresa Lluesma Ballesteros, Farzad Arbabi, Johannes Geiger, Christian Dohmen, Christian Plank, Rebecca Kinsley, Ralf Wagner, Jonathan Luke Heeney

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