Medicine and Health

Computational identification of HCV neutralizing antibodies with a common HCDR3 disulfide bond motif in the antibody repertoires of infected individuals

N. G. Bozhanova, A. I. Flyak, et al.

Discover groundbreaking research addressing the need for an HCV vaccine despite successful antiviral treatments. This study by Nina G. Bozhanova, Andrew I. Flyak, and others revealed new broadly neutralizing antibodies with unique structural features that could reshape the future of HCV prevention.

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Abstract

Despite successful HCV treatment with antivirals, an HCV vaccine is crucial to prevent reinfections, drug resistance, and protect those lacking access to antivirals. Early broadly neutralizing antibodies (bNAbs) correlate with HCV clearance. Many potent bNAbs bind a conserved HCV glycoprotein E2 epitope via an unusual HCDR3 with an intra-loop disulfide bond. This study identifies new antibodies with this HCDR3 disulfide bond motif using computational screening (Rosetta software). Analysis of this antibody family reveals HCDR3 amino acid composition and determinants for bent versus straight HCDR3 loop conformations.

Publisher

Nature Communications

Published On

Jun 08, 2022

Authors

Nina G. Bozhanova, Andrew I. Flyak, Benjamin P. Brown, Stormy E. Ruiz, Jordan Salas, Semi Rho, Robin G. Bombardi, Luke Myers, Cinque Soto, Justin R. Bailey, James E. Crowe Jr., Pamela J. Bjorkman, Jens Meiler

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